Rotary International Theme 2022-2023
Rotary Club of
Rotary International President:
Jennifer E. Jones
Rotary District 5160 Governor:
Durham Rotary President: Eric Hoiland
Editor: Phil Price
Publisher:† Jen Liu
October 25, 2022
CRAB FEED 2023
CRAB FEED 2023
January 21, 2023
|2022 Calendar for Durham Rotary|
Camp Royal Students
at Durham Memorial Hall
Tour of Airspray
Thank you Peggi Koehler for taking notes of the meeting for me, since I was out with Covid.
The Meeting Opening
At Ravi Saipís invitation, the meeting was called to order by President Eric Hoiland, at Air Spray, located at the Chico Municipal Airport. †
He asked Ravi Saip to lead the pledge, which he did.† He then asked Jim Patterson to present the invocation, which he did.†† Larry Bradley then led us in singing a patriotic song.
Dinner was pizza with salad organized by President Eric.
FUTURE MEETINGS: Meetings will be at the location noted, at 6:00 pm.
November 8th:† Mike Wacker, at BCCC.
November 28th (Monday) for Monday Night Football. Stay tuned for location.
December 6th:† Holiday Party at BCCC.
December 14th:†† Bruce Norlie.† Location undetermined.
January ??:† Unknown
January 21st:† Crab Feed
The Crab Feed is January 21st.† There will be a Zoom planning meeting on November 15th.† Kristen Cargile encouraged members to begin securing donations for the Silent Auction NOW.
The next meeting (November 8th) will be at the Butte Creek Country Club.† The following meeting will be a Monday Night Football meeting on Monday November 28th.† Location not yet determined.
The next meeting will be on November 8th.† Mike Wacker will present the program about the Durham Volunteer Fire Department and the Jaws of Life they use.† It will be held at the Butte Creek Country Club.
Peggi Koehler had a birthday on October 18th.† She contributed $60.† Happy Birthday was sung.† [I thought traditionally that birthdays were $10 if you had a song and $15 if you elected not to have a song].
Ravi suggested that we should recognize Jenís birthday, even though he is out of the country visiting Pamís mother in Taiwan.† He was recognized in the amount of $50.
Mike Wacker had his 34th wedding anniversary, but since he is the current holder of the Grinder, he was exempt from making any contribution.
Introduction of Visitors.
Introduced were Maura Polk, Darylís daughter, Dennis Cargile, Kristenís husband, and Tom Knowles, a former member, who hopefully will rejoin.
Tonightís Meeting Program
Tonightís meeting was in the massive AirSpray hanger at the Chico Muncipal Airport.† The atmosphere and ambiance was all about aircraft and aviation.† Raviís explanation †of so much information was extremly informative, but near impossible to put into notes.† Much of it was about the various aircraft used for wilefire management.† There were two of AirSpray aircraft being worked on and members were able to climb on and in them.† Basically the fuselages were hollow inside.† What gets† build inside the hollow fuselageís are massive water or flame retardent containers.† Fire Boss, an amphibious air tractor 802F Scooper Bomber was on display.† It is able to scoop water from an open water source and return to a fire† multiple times† (I observed this being done from the north end of Lake Almanor during the Dixie Fire).††† Also on display was a larger AirSpray Airtanker which delivers up to 3,000 gallons of fire retardent.†† Ravi shared much information† from his over 40 years in aviation and his time as General Manager of AirSpray and now Quality Control Director.
Bring guests who you think you can interest in becoming a member.† Think of business owners or managers to bring.† Your dinner and your guestís dinner will be paid for by the Club.† Also, bring a guest to one of our occasional social gatherings in the Durham Park or a Pizza place (Monday Night Football).
Go to the following Rotary International web site for information on membership development:† https://my.rotary.org/en/learning-reference/learn-topic/membership .† From this website there is access to membership development and other related information
The Rotary Foundation Donations
You can make a difference in this world by helping people in need. Your gift can do some great things, from supplying filters that clean peopleís drinking water to empowering local entrepreneurs to grow through business development training.
The Rotary Foundation will use your gift to fund the life-changing work of Rotary members who provide sustainable solutions to their communitiesí most pressing needs. But we need help from people like you who will take action and give the gift of Rotary to make these projects possible.
When every Rotarian gives every year, no challenge is too great for us to make a difference. The minimum gift to The Rotary Foundation is $25.00. An annual $100.00 gift is a sustaining member. Once your donations accumulate to $1,000 you become a Paul Harris Fellow.
It is possible to learn more about The Rotary Foundation on the Rotary web site.
Your gift can be made online or by sending Jessica Thorpe a check made out to The Rotary Foundation to Durham Rotary, P.O. Box 383, Durham, California 95958.
Must Be Present to Win Drawing:
Eric then closed the meeting.
From the District
From Rotary International
In mid-2017, two groups of 15 strangers lived together for 28 days each in a ring of shipping containers assembled in the parking lot of Antwerp University Hospital in Belgium. They had access to books and movies, a small courtyard for barbecues, a common kitchen and dining room, and a fitness room ó all of it behind secure interlocking doors and under the watch of personnel in protective gowns.
What sounds like a reality TV or sci-fi scenario was, in fact, a remarkable clinical trial of the latest weapon in the battle to eradicate polio ó a reengineered vaccine called the novel oral polio vaccine type 2, or nOPV2. The study aimed to evaluate whether the altered formula, the first major update to polio vaccines in about six decades, could help end outbreaks of circulating vaccine-derived poliovirus, also known as variant poliovirus. Such cases arise in rare instances when the live but weakened virus contained in oral polio vaccines circulates in areas of low vaccine coverage and mutates back into a dangerous form that can infect people who have not been fully vaccinated.
These variant poliovirus outbreaks have emerged over the past two decades as a significant stumbling block in the effort by Rotary and its partners in the Global Polio Eradication Initiative (GPEI) to wipe out the disease. The outbreaks are different from those driven by wild poliovirus, which circulated naturally in the environment for millennia and remains endemic in just two countries, Afghanistan and Pakistan. But the outcome is the same ó the virus in either kind of outbreak can, in rare instances, cause paralysis.
In 2011, staff at the Bill & Melinda Gates Foundation, one of the GPEI partners, wondered if the live virus in the traditional oral vaccine could be tweaked to limit its ability to mutate. "The first challenge was purely scientific," says Ananda Bandyopadhyay, a deputy director of the polio team at the Gates Foundation, which funded and led the effort. "How do you make the vaccine more genetically stable without compromising its immunogenicity [ability to provoke an immune response]? That was really, really challenging."
Even then, researchers would need to figure out how to test the idea. Any attempt would require strict isolation of study participants. At a 2015 meeting in Brussels, Bandyopadhyay pitched the audacious idea to Pierre Van Damme, director of the Centre for Evaluation of Vaccination at the University of Antwerp. "We had to be very creative," says Ilse De Coster, who would lead the clinical trial team with Van Damme in Belgium, "because at that time we didn't have any facility that was developed for containment."
At Poliopolis, a purpose-built container village in Antwerp, Belgium, nOPV2 vaccine trial participants had to live together for 28 days, sealed off from the outside world. ďIt was surreal,Ē says Caro Bouten, a volunteer from the Netherlands whose aunt had polio.
They considered sequestering study participants at isolated holiday resorts or vacant centers that had been used to house asylum seekers, eventually settling on the idea of a purpose-built modular container village, dubbed Poliopolis by Van Damme's wife. The center's scientists had conducted more than 500 vaccine trials but had little experience with polio, which long ago ceased to be of daily concern in the country thanks to routine immunization.
For much of the developed world, polio is a distant memory. Long gone are the days of the summertime terrors in Europe and North America in the 1940s and 1950s when children went to bed with what their parents thought was a mild flu only to wake up rubber-limbed and burning with fever. Thousands were paralyzed. Some ended up in the dreaded iron lung device that enclosed the body up to the neck and helped them breathe.
There is no cure for polio, but with the development of vaccines in the 1950s and subsequent routine immunization, the United States and Belgium saw their last wild polio cases in 1979. Vaccination campaigns went global in the decades that followed, with Rotary launching PolioPlus in 1985 and helping found the GPEI in 1988. The goal was to eradicate a human disease for only the second time in history, after the World Health Organization declared the world free of smallpox in 1980.
In 1988, wild poliovirus paralyzed hundreds of children every day, with an estimated 350,000 polio cases across more than 125 countries that year. Since then, cases have plummeted 99.9 percent, sparing an estimated 20 million children from paralysis. From January to early August of this year, 14 cases of wild polio were confirmed in Pakistan and one in Afghanistan ó the last two countries where it is consistently present. Four additional cases were reported in Mozambique in an outbreak that began in Malawi in late 2021 and was linked to a virus strain that had circulated in Pakistan.
That progress would not have been possible without the oral polio vaccine. "It's a critically important tool and has saved millions of lives and prevented paralysis," Bandyopadhyay says.
A polio vaccination team visits a home in Karachi, Pakistan, in August. More than 60 percent of vaccine workers in the country are women, helping to build trust and convince mothers to vaccinate their children.
The oral polio vaccine, or OPV, was developed in the late 1950s by physician Albert Sabin. It's become the vaccine of choice for polio eradication because it's safe, inexpensive, and easy to administer, and the live but weakened vaccine virus replicates in the gut and produces strong intestinal immunity. As a result, vaccinated children can shed the weakened vaccine virus in their stool for several weeks. In areas with poor sanitation, the weakened virus spreads, stimulating an immune response in the unvaccinated. But this ability of the weakened virus to circulate carries the risk of seeding vaccine-derived, or variant, outbreaks in areas of low immunity.
Most variant cases involve type 2 poliovirus, one of two strains that have been eradicated in the wild. The number of children paralyzed by the type 2 variant poliovirus surged from two in 2016 to more than 1,000 at its peak in 2020, spread over two dozen countries, most of them in Africa. The situation was made worse by a four-month halt to immunization campaigns during the COVID-19 pandemic that left 80 million children unprotected. "It created a window for further expansion of the outbreaks," says John Vertefeuille, chief of the polio eradication branch at the U.S. Centers for Disease Control and Prevention. Variant cases now vastly outnumber cases of wild polio, though they are starting to decline.
The existing oral polio vaccine containing only type 2 virus has been effective in stopping most variant poliovirus outbreaks. But still, that vaccine carries the risk of the virus mutating back to a more virulent form if it circulates in populations with low immunity. At the Gates Foundation, there was a realization that a new type 2 oral polio vaccine was needed, and fast. "This entire situation with the variant poliovirus outbreaks is a challenge, but it's also an opportunity to innovate," Bandyopadhyay says.
The foundation established and funded a scientific consortium to develop the new oral vaccine, including the UK's National Institute for Biological Standards and Control and the University of California San Francisco. Researchers at those two institutions altered part of the old type 2 vaccine virus's genome to make it more genetically stable while preserving its ability to produce strong immunity in the gut. But the challenge of how to test it in humans without risking environmental spread remained.
"This entire situation with the variant poliovirus outbreaks is a challenge, but itís also an opportunity to innovate."
The team at Poliopolis was moving fast. The 66 containers, which were prefabricated off-site, were assembled in just three days in April 2017 and were ready for operation a month after that. Altogether, it had been less than half a year since the team decided to proceed with the Poliopolis concept. To the researchers' knowledge, no one had ever attempted a containment study in such a purpose-built facility and for so long.
Other vaccine trials requiring containment measures have been carried out in hospitals and even motels. But since vaccinated people shed the weakened virus from the oral polio vaccine in their stool for several weeks, researchers would need a facility where sewage could be strictly contained, kept separate from public waste systems, and decontaminated. Clothing, towels, utensils, uneaten food, and anything else handled by participants would be disposed of securely or decontaminated with chlorine dioxide gas. Entrances were interlocking, meaning an inner door could not open until an outer one locked.
Poliopolis was constructed in just three days. To the researchersí knowledge, no one had ever attempted a containment study quite like it. Volunteers had to undergo medical and psychological screenings to ensure they were up to the challenge and could function as a group.
Because of the length of time the virus can continue to be excreted, trial participants would have to stay sequestered for at least 28 days. Volunteers had to undergo medical and psychological screening to ensure they were up to the challenge and could function as a group. "We had two psychologists who screened the subjects," says De Coster, adding that participants had access to mental health support throughout the trial.
Volunteers, most from neighboring Netherlands, included a housewife, a student finishing a master's thesis, and a working professional who wanted a little time off. They got along well despite occasional friction over insignificant things like messes in the kitchen. "Put some people together and there will be friction, like on the reality TV show Big Brother," explains Caro Bouten, one of the volunteers. "I was writing a book, so I didn't care. I'd go back to my room. I had a focus. So that helped me."
Polio left Bouten's aunt with a limp, a leg brace, and a difficult life at a boarding school, separated from a family that felt ashamed of the condition. Those memories, along with her work as a nurse and counselor for refugees, motivated her to join the study. She realized just how important it was afterward when she was invited to meet the queen of Belgium.
NOPV2 received the first-ever emergency use listing for a vaccine by the WHO in November 2020. The vaccine was rolled out in March 2021, first in Nigeria and Liberia. Through the first half of 2022, more than 370 million doses were administered in more than 20 countries.
"It's looking very promising, and it's looking like it's doing what it is supposed to do: induce population immunity and interrupt transmission in most settings and with a much lower risk of seeding new outbreaks," Bandyopadhyay says.
A polio vaccinator marks a childís pinkie after vaccinating him outside a home in Karachi, Pakistan. By early August of this year, 14 cases of wild polio were confirmed in Pakistan and one in neighboring Afghanistan ó the last two countries where wild poliovirus is endemic.
The new vaccine, by itself, is not a silver bullet. It won't stop transmission if immunization campaigns cannot reach close to 90 percent of children in the response zones. Integrating polio response with other important community needs is key to gaining trust and cooperation, campaigners say. That's crucial because under-immunization remains an obstacle, allowing cases of variant polio to leap across the globe and pop up in places where the disease hasn't been seen in years. Officials detected polio in London and New York City sewage this year, for instance. And in July 2022, health authorities announced an unvaccinated man in New York state had been sickened with variant poliovirus genetically linked to the spread in London.
We've never been closer than we are now has been a frequent refrain for the polio eradication campaign, but there are plenty of reasons to believe it today. The global community is united around the latest GPEI strategy. The Taliban leadership that returned to power in Afghanistan a year ago agreed to allow house-to-house immunization campaigns to resume nationwide after a 3 Ĺ-year ban in some areas. And there are more scientific innovations in the pipeline.
Like many polio campaigners, Nana Yaa Siriboe, a member of the Rotary Club of Accra Labone, Ghana, has a personal stake in crossing the finish line. Her cousin is a survivor who once needed crutches but now walks unaided, with only a limp. "My mother would tell her, 'I'm not going to allow you to think that you're going to be helpless,'" she recalls. "And I tell you, my cousin is a fighter."
Siriboe became chair of the Ghana PolioPlus Committee in 2019, just as variant polio cases were emerging in the country, about a decade after it was declared polio-free. She mobilized Rotary volunteers to visit homes, schools, mosques, churches, and markets to find and immunize children, and the outbreaks were suppressed for two years. But polio paralyzed one person this June, prompting another mass immunization campaign that was to start in August.
The arrival of nOPV2 gives her hope. So do the mothers she has watched over the years bringing their children to be vaccinated. "It's a joy," she says of meeting the children. "You get to play with them. Some like to see their little finger marked with the pen to show this child has been immunized. We give them toffee. It's a wonderful experience."
This story originally appeared in the October 2022 issue of Rotary magazine.
The Rotary International web site is: www.rotary.org
District 5160 is: www.rotary5160.org
The Durham Rotary Club site is: www.durhamrotary.org
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